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The mechanism for the formation of may proceed via the initial attack of a water molecule at the selenium center in compound followed by a nucleophilic attack of the selenium-bound oxygen atom at the carbonyl carbon of one of the amide moieties, leading to the formation of an intermediate (Figure 8) [59]

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Cardiac hypertrophy due to heart failure and ventricular remodeling Heart failure is a kind of disease that the impaired heart function or structure causes decreased ventricular filling or decreased ejection function, and the heart output is not enough to meet the needs of the body

Although the above discussed studies suggested a considerable association between the selenium-induced GPx level and the radiation resistance of cultured cells and murine models, it can be argued that the direct cause and effect relationship between GPx activity/expression and radiation toxicity was lacking in these studies

eLife 3 , e02451 (2014) Doroghazi, J

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